{"product_id":"cst-54390s","title":"CST,  54390S, Fibrinogen beta chain Antibody","description":"Polyclonal Antibody for studying FGB. Validated for Western Blotting. Highly specific and rigorously validated in-house, Fibrinogen beta chain Antibody (CST #54390) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nFibrinogen beta chain Antibody recognizes endogenous levels of total fibrinogen beta chain protein. This antibody does not cross-react with either fibrinogen Aα or fibrinogen γ proteins.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn190 of human fibrinogen beta chain protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nFibrinogen is a large, multimeric plasma glycoprotein that is constitutively synthesized by liver hepatocytes. As a key component of blood clots, fibrinogen plays a central role in hemostasis and thrombosis. In total, six polypeptide chains (2Aα, 2Bβ, and 2γ) are produced intracellularly in a coordinated manner, which are then covalently linked together by a network of disulfide bonds to form a fibrinogen heterohexamer (1). Research studies have shown that expression of the three fibrinogen genes is upregulated as part of the acute phase inflammatory response (2,3). Upon engagement of the clotting cascade, thrombin-mediated cleavage of the fibrinogen Aα and Bβ chains creates fibrin monomers and a platform for the polymerization of fibrin monomers into protofibrils and an insoluble web of stable fibrin fibers (4,5). Whereas thrombin is the enzyme that drives fibrin polymerization and clot formation, plasmin is the enzymatic counterpart that facilitates fibrinolysis and clot breakdown (6). In addition to its position as a central node in the normal coagulation cascade, dysregulated fibrin deposition has been observed in pathological conditions such as cancer and viral infection (7,8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nbeta-fibrinogen; epididymis secretory sperm binding protein Li 78p; FGB; FIBB; Fibrinogen beta chain; fibrinogen, B beta polypeptide; fibrinogen, beta chain; Fibrinopeptide B; HEL-S-78p; MGC104327; MGC120405\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 55\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799809511593,"sku":"54390S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-54390s","provider":"Iright","version":"1.0","type":"link"}