{"product_id":"cst-54678s","title":"CST,  54678S, LY-364947","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nLY-364947 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.22 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nLY-364947, also known as HTS-466284, is a potent and selective TGF-β type-I receptor (TGF-β RI, TGFR-I, TβR-I, ALK-5) inhibitor. This small molecule specifically targets TGF-β RI with an IC value of 59 nM and is less effective on TGF-β RII and MLK-7K (IC values of 400 nM and 1400 nM, respectively) (1). LY-364947 regulates MDA-MB-231 cell invasion by inhibiting autocrine TGF-β signaling (2). Patients in intensive care units (ICUs) that suffer from chronic sepsis can experience weakening of the diaphragm muscles caused by muscle wasting, requiring mechanical ventilation. Members of the TGF-β family can trigger the activation of protein breakdown. Inhibition of the TGF-β pathway can protect the diaphragm during chronic sepsis, making LY-364947 an interesting compound to study as it relates to effective ICU patient care (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinolone; HTS 466284; HTS-466284; HTS466284; TGF-beta inhibitor; TGF-β RI Kinase Inhibitor; Transforming Growth Factor-β Type I Receptor Kinase Inhibitor","brand":"CST","offers":[{"title":"Default Title","offer_id":46800696246441,"sku":"54678S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-54678s","provider":"Iright","version":"1.0","type":"link"}