{"product_id":"cst-54710t","title":"CST,  54710T, Presenilin 2 (F7E5Q) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Presenilin-2. Validated for WB,WB,IP,IHC. Available in 2 sizes. Highly specific and rigorously validated in-house, Presenilin 2 (F7E5Q) Rabbit Monoclonal Antibody (CST #54710) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\nImmunoprecipitation: 1:50\nImmunohistochemistry (Paraffin): 1:200 - 1:800\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPresenilin 2 (F7E5Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total Presenilin 2 protein. This antibody does not cross-react with Presenilin 1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr345 of human Presenilin 2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPresenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer disease, probably due to presenilin's associated γ-secretase activity for amyloid-β protein processing (1,2). Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (~20, 22, 23 kDa) fragments (CTF) (2,3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAD3L; AD3LP; AD4; AD5; Alzheimer disease 4; Alzheimer's disease 3-like; CMD1V; E5-1; presenilin 2; presenilin 2 (Alzheimer disease 4); Presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS-2; PS2; PSEN2; PSN2; PSNL2; STM-2; STM2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 23 (C-terminal fragment), 54 (full-length)\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799812231337,"sku":"54710T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-54710t","provider":"Iright","version":"1.0","type":"link"}