{"product_id":"cst-54922s","title":"CST,  54922S, MYO10 (F3V7U) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MYO10. Validated for Western Blotting,Immunoprecipitation,Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, MYO10 (F3V7U) Rabbit Monoclonal Antibody (CST #54922) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\nImmunofluorescence (Immunocytochemistry): 1:50 - 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMYO10 (F3V7U) Rabbit Monoclonal Antibody recognizes endogenous levels of total MYO10 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the central region of human MYO10 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMyosin family motor proteins drive ATP-dependent actin-based motility in eukaryotic cells and contain a conserved amino-terminal motor domain (1). Unconventional myosin-X (MYO10) binds actin filaments and localizes to filopodia tips. MYO10 regulates cell migration, metastasis, and neuritogenesis, and its expression is upregulated in mouse and human tumors (2). MYO10 was shown to drive tumor progression by inducing genome instability through cGAS\/STING inflammatory response (3). Regulation of MYO10 phosphorylation and protein levels in mitosis is critical for spindle formation, genome stability, and sensitivity of cancer cells to Taxol (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLJ10639; FLJ21066; FLJ22268; FLJ43256; KIAA0799; MGC131988; MYO10; myosin X; Myosin-X; Unconventional myosin-10; Unconventional myosin-X; unconventionnal myosin-X\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 237\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799813771433,"sku":"54922S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-54922s","provider":"Iright","version":"1.0","type":"link"}