{"product_id":"cst-55106sf","title":"CST,  55106SF, SHOC2 (D7N1A) Rabbit Monoclonal Antibody (BSA and Azide Free)","description":"Monoclonal Antibody for studying SHOC2. Validated for Western Blotting. Highly specific and rigorously validated in-house, SHOC2 (D7N1A) Rabbit Monoclonal Antibody (BSA and Azide Free) (CST #55106) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nThis product is the carrier free version of product #53600. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol. This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT\u0026amp;RUN or CUT\u0026amp;Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us . Optimal dilutions\/concentrations should be determined by the end user. BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.\n\u003cb\u003eFormulation\u003c\/b\u003e\nSupplied in 1X PBS (10 mM Na 2 HPO 4 , 3 mM KCl, 2 mM KH 2 PO 4 , and 140 mM NaCl (pH 7.8)). BSA and Azide Free. For standard formulation of this product see product # 53600\n\u003cb\u003eStorage\u003c\/b\u003e\nStore at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze\/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSHOC2 (D7N1A) Rabbit Monoclonal Antibody (BSA and Azide Free) recognizes endogenous levels of total SHOC2 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human SHOC2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSHOC2 is a scaffolding protein that harbors multiple leucine-rich repeats in tandem and is an upstream positive regulator of growth factor-dependent MAPK\/ERK signaling. Research studies have demonstrated that SHOC2 forms a complex with the catalytic subunit of the PP1 phosphatase and M-Ras, and this complex drives activation of Raf-ERK signaling in response to mitogenic growth factors (1). SHOC2 has also been shown to cross-talk with and activate the PI3K\/Akt signaling axis through its interaction with the p110α catalytic subunit of PI3K (2). As a positive regulator of ERK and PI3K\/Akt signaling cascades, SHOC2 has been implicated in the regulation of several oncogenic cellular processes such as cell motility, invasion, and metastasis (2). A mutation in that introduces an N-terminal myristoylation site, promotes aberrant membrane targeting of SHOC2, hyperactive MAPK\/ERK signaling, and Noonan-like syndrome (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLJ60412; KIAA0862; Leucine-rich repeat protein SHOC-2; NSLH1; Protein soc-2 homolog; Protein sur-8 homolog; SHOC2; SHOC2 leucine rich repeat scaffold protein; SIAA0862; SOC-2; soc-2 suppressor of clear homolog; soc-2 suppressor of clear homolog (C. elegans); SOC2; suppressor of clear, C. elegans, homolog of; SUR-8; SUR8\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 64\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799814951081,"sku":"55106SF","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-55106sf","provider":"Iright","version":"1.0","type":"link"}