{"product_id":"cst-55199s","title":"CST,  55199S, Mitochondrial Fusion Promoter M1","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nMitochondrial Fusion Promoter M1 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 0.92 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles .\n\u003cb\u003eBackground\u003c\/b\u003e\nMitochondrial Fusion Promoter M1 is a hydrazone compound that promotes mitochondrial fusion in fragmented mitochondria (1). In a study of human induced pluripotent stem cells (iPSCs), M1 fused fragmented mitochondria and promoted the differentiation of iPSCs into an early mesodermal cardiac lineage (2). Pancreatic β cells treated with soluble cholesterol triggers increased total cholesterol accumulation, diminished cellular respiration, and compromised glucose-stimulated insulin secretion. Treatment of these cells with M1 prevents cholesterol-mediated suppression of cellular respiration and increases glucose-stimulated insulin secretion (3). M1 is also seen to protect against brain damage in rats with induced cardiac ischemia\/reperfusion (I\/R) injury (4) and against diabetic cardiomyopathy in a rat model of diabetes (5). Treatment of donor microvascular endothelial cells with M1 and the fission inhibitor Mdivi1 promotes mitochondrial fusion and reduces recipient T cell responses, which may lead to improved cardiac transplant survival (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n(E)-4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol; 1-(5-Chloro-2- hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone","brand":"CST","offers":[{"title":"Default Title","offer_id":46800696311977,"sku":"55199S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-55199s","provider":"Iright","version":"1.0","type":"link"}