{"product_id":"cst-55521s","title":"CST,  55521S, AP2A2 (E9Q1O) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying AP2A2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, AP2A2 (E9Q1O) Rabbit Monoclonal Antibody (CST #55521) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAP2A2 (E9Q1O) Rabbit Monoclonal Antibody recognizes endogenous levels of total AP2A2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro800 of human AP2A2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe adaptor-protein 2 (AP-2) coat assembly protein complex is an important component of clathrin-coated pits involved in receptor-mediated endocytosis at the plasma membrane (1-3). Each AP-2 heterotetramer is composed of α, β, μ, and σ protein subunits. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into clathrin-coated vesicles destined for incorporation into the endosomal compartment. AP-2 complex subunit alpha-2 (AP2A2) is one of two large alpha-type adaptins that exist within the AP-2 complex. Research studies have shown that AP2A2 works in concert with AP-2 sigma subunits to facilitate the recognition of [ED]-X-X-X-L-[LI] endocytic motifs embedded within the cytoplasmic tails of membrane cargo proteins destined for the endosomal compartment (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n100 kDa coated vesicle protein C; Adapter-related protein complex 2 alpha-2 subunit; adapter-related protein complex 2 subunit alpha-2; adaptin, alpha B; Adaptor protein complex AP-2 subunit alpha-2; adaptor related protein complex 2 alpha 2 subunit; adaptor related protein complex 2 subunit alpha 2; Adaptor-related protein complex 2 subunit alpha-2; adaptor-related protein complex 2, alpha 2 subunit; ADTAB; Alpha-adaptin C; Alpha2-adaptin; AP-2 complex subunit alpha-2; AP2A2; CLAPA2; Clathrin assembly protein complex 2 alpha-C large chain; clathrin-associated\/assembly\/adaptor protein, large, alpha 2; HIP-9; HIP9; Huntingtin interacting protein J; Huntingtin yeast partner J; Huntingtin-interacting protein 9; Huntingtin-interacting protein J; HYPJ; KIAA0899; Plasma membrane adaptor HA2\/AP2 adaptin alpha C subunit\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 105\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799818293417,"sku":"55521S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-55521s","provider":"Iright","version":"1.0","type":"link"}