{"product_id":"cst-55598s","title":"CST,  55598S, Parvalbumin Antibody","description":"Polyclonal Antibody for studying Parvalbumin. Validated for Western Blotting. Highly specific and rigorously validated in-house, Parvalbumin Antibody (CST #55598) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nParvalbumin Antibody recognizes endogenous levels of total parvalbumin protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human parvalbumin protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nParvalbumin (PV, PVALB) is a member of the EF-hand family of calcium-binding proteins, containing EF-hand domains with a high affinity for calcium and magnesium (1). Parvalbumin is expressed in both the soma and in processes of specific subclasses of GABAergic interneurons. Parvalbumin is a slow calcium buffer, meaning it accelerates the initial phase of decay of calcium after an action potential, which likely inhibits facilitation and is thought to regulate short-term synaptic plasticity (2,3). Altered function of PV positive interneurons has been implicated in many neurological diseases, such as Alzheimer's disease, autism spectrum disorder, schizophrenia, and bipolar disorder (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nD22S749; MGC116759; parvalbumin; Parvalbumin alpha; PRVA; PVA; PVALB\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 12\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799819145385,"sku":"55598S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-55598s","provider":"Iright","version":"1.0","type":"link"}