{"product_id":"cst-55633s","title":"CST,  55633S, Kir4.1 (F5Z2T) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Kir4.1 mouse. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, Kir4.1 (F5Z2T) Rabbit Monoclonal Antibody (CST #55633) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:400 - 1:1200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nKir4.1 (F5Z2T) Rabbit Monoclonal Antibody recognizes endogenous levels of total Kir4.1 protein. Non-specific staining was observed in smooth and cardiac muscle tissue by immunohistochemistry.\nSpecies Reactivity: Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro339 of mouse Kir4.1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nInwardly rectifying potassium (Kir) channels containing Kir4.1 subunits (Kir4.1 channels) are expressed exclusively in glial cells in the central nervous system (CNS) (1). These channels provide a spatial buffering system for potassium ions, playing an important role in maintaining neuronal excitability (1-3). Astrocytic Kir4.1 channels have a pathophysiological role in epilepsy, Fragile X syndrome, chronic pain, and depression (2,4,5). Furthermore, Kir4.1 channels are expressed in oligodendrocytes. Oligodendric potassium clearance has been found critical for sustained axonal function and integrity (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nATP-sensitive inward rectifier potassium channel 10; BIR; BIR10; BIRK; BIRK-1; inward rectifier K(+) channel Kir4.1; KCJ10; Kcnj10; Kcnj10 protein; Kir1; Kir1.2; Kir4; Kir4.1; potassium channel, inwardly rectifying subfamily J member 10; potassium inwardly-rectifying channel, subfamily J, member 10\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M R\nSENSITIVITY: Endogenous\nMW (kDa): 42, 140, 180\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800103407785,"sku":"55633S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-55633s","provider":"Iright","version":"1.0","type":"link"}