{"product_id":"cst-55653t","title":"CST,  55653T, C1R (E3R7T) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying C1R. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, C1R (E3R7T) Rabbit Monoclonal Antibody (CST #55653) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nC1R (E3R7T) Rabbit Monoclonal Antibody recognizes endogenous levels of total C1R protein. This antibody reacts with C1R proenzyme and C1R A (heavy) chain proteins.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human C1R protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nComplement C1R subcomponent (C1R) is a secreted serine protease module of the C1 macromolecular complex, which is a central node in complement activation via the classical pathway. Each C1 complex is stabilized by divalent calcium cations and contains, in part, a non-covalent dimer of identical C1R monomers that interact with the C1Q component of the C1 macromolecular complex (1). Each C1R monomer is synthesized as a proenzyme and is auto-activated within the C1 complex upon recognition of antigen-antibody complexes by C1Q (2,3). Activation of C1R leads to its cleavage into a disulfide-linked amino-terminal A (heavy) chain and a carboxyl terminal B (light) chain. The B chain contains serine protease activity that triggers a cascade of downstream enzymatic reactions that govern the classical pathway of complement (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC1R; complement C1r; Complement C1r subcomponent; Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain; Complement component 1 subcomponent r; complement component 1, r subcomponent; EDSPD1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 95,55\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799819505833,"sku":"55653T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-55653t","provider":"Iright","version":"1.0","type":"link"}