{"product_id":"cst-5617s","title":"CST,  5617S, Phospho-ARHGAP42 (Tyr376) (D45E9) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ARHGAP42 (Tyr376) phosphate. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Phospho-ARHGAP42 (Tyr376) (D45E9) Rabbit Monoclonal Antibody (CST #5617) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPhospho-ARHGAP42 (Tyr376) (D45E9) Rabbit Monoclonal Antibody detects endogenous levels of ARHGAP42 only when phosphorylated at Tyr376.\nSpecies Reactivity: Human, Mouse, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr376 of human ARHGAP42 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nARHGAP family members activate Rho GTPase proteins (1). Mutations of ARHGAP family genes lead to carcinogenesis through the dysregulation of Rho\/Rac\/Cdc42-like GTPases (2). Little is known about the biological function of ARHGAP42, a member of the ARHGAP family. ARHGAP42 contains a RhoGAP domain in the middle of its sequence, an SH3 binding domain at the C-terminal end of the protein sequence, as well as a BAR domain and a PH domain in the N-terminal region of the sequence, which indicate that the protein may function as GTPase activator and cytoskeletal adaptor.\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAD031; ARHGAP42; FLJ32810; GRAF3; KIAA0621; RHG42; Rho GTPase activating protein 42; rho GTPase-activating protein 10-like; Rho GTPase-activating protein 42; Rho GTPase-activating protein FLJ32810; Rho-type GTPase-activating protein 42; Rho-type GTPase-activating protein FLJ32810; TMEM133; transmembrane protein 133; YK021\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M Mk\nSENSITIVITY: Endogenous\nMW (kDa): 125\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799823306921,"sku":"5617S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-5617s","provider":"Iright","version":"1.0","type":"link"}