{"product_id":"cst-56551t","title":"CST,  56551T, DOCK5 (E6R9W) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying DOCK5. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, DOCK5 (E6R9W) Rabbit Monoclonal Antibody (CST #56551) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nDOCK5 (E6R9W) Rabbit Monoclonal Antibody recognizes endogenous levels of total DOCK5 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro1863 of human DOCK5 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nRho family small GTPases act as molecular switches, regulating processes such as cell migration, adhesion, proliferation, and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and are inhibited by GTPase activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP (1). DOCK5 (dedicator of cytokinesis 5) is a Rho family GEF that plays an essential role in generating the sealing zone, an osteoclast-specific adhesion structure that mediates bone resorption and is regulated by actin and microtubule cytoskeletal signaling. Due to its role in bone resorption, DOCK5 is a potential therapeutic target for osteoporosis (2-4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\ndedicator of cytokinesis 5; Dedicator of cytokinesis protein 5; DKFZp451J181; DKFZp779M164; DKFZp781J211; DOCK5\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 215\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799826583721,"sku":"56551T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-56551t","provider":"Iright","version":"1.0","type":"link"}