{"product_id":"cst-56572s","title":"CST,  56572S, MXRA8 (E7K5Q) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MXRA8\/Limitrin. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MXRA8 (E7K5Q) Rabbit Monoclonal Antibody (CST #56572) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMXRA8 (E7K5Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total MXRA8 protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MXRA8 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMXRA8 (Matrix remodeling-associated protein 8), also known as DICAM or limitrin, is a dual immunoglobulin domain containing cell adhesion molecule expressed on epithelial, myeloid, and mesenchymal cells. A single-pass type I transmembrane protein that is highly expressed at areas of cell-cell contact and may localize to tight junctions, MXRA8 mediates cell adhesion via interaction with αVβ3 integrin (1). Through its interactions with integrins, MXRA8 has been shown to suppress both angiogenesis (2) and osteoclast differentiation (3) by attenuating p38 mitogen-activated protein (MAP) kinase signaling. MXRA8 also plays a pivotal role in ferroptosis and the immune microenvironment of glioma, suggesting that it may serve as a novel prognostic marker and therapeutic target (4). A recent study showed that multiple emerging arthritogenic alphaviruses, including CHIKV, RRV, MAYV, and ONNV, use MXRA8 as a functional receptor (5). Structural insights into how Chikungunya virus particles bind MXRA8 to enhance viral attachment and internalization into cells may provide a guide for developing antiviral therapies against arthritogenic alphaviruses (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nASP3; DKFZp586E2023; Limitrin; matrix remodeling associated 8; Matrix remodeling-associated protein 8; Matrix-remodeling-associated protein 8; matrix-remodelling associated 8; MGC3047; MXRA8\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 48-62\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799826878633,"sku":"56572S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-56572s","provider":"Iright","version":"1.0","type":"link"}