{"product_id":"cst-56844s","title":"CST,  56844S, APOBEC3A (E6K2O) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying APOBEC3A. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, APOBEC3A (E6K2O) Rabbit Monoclonal Antibody (CST #56844) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAPOBEC3A (E6K2O) Rabbit Monoclonal Antibody recognizes endogenous levels of total APOBEC3A protein. This antibody does not cross-react with APOBEC3B or APOBEC3G proteins. Based on the sequence of the immunogenic peptide, this antibody is not expected to detect isoform 2 of APOBEC3A.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro9 of human APOBEC3A protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMembers of the APOBEC3 subfamily of cytosine deaminases (APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H) function in innate immunity by preventing viral DNA replication, including that of HIV-1 (1-2). APOBEC3A expression is upregulated in several human cancers, and is a major source of mutation in breast cancer (3). APOBEC3A contributes to chromosomal instability and disease progression in pancreatic cancer (4), and upregulates PD-L1 expression in cancer cells (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nA3A; ABC3A; APOBEC3A; apolipoprotein B mRNA editing enzyme catalytic subunit 3A; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A; ARP3; bK150C2.1; DNA dC-\u0026gt;dU-editing enzyme APOBEC-3A; phorbolin 1; Phorbolin-1; PHRBN; Probable DNA dC-\u0026gt;dU-editing enzyme APOBEC-3A\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 23\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800990470313,"sku":"56844S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-56844s","provider":"Iright","version":"1.0","type":"link"}