{"product_id":"cst-5687t","title":"CST,  5687T, PPP2R5D (H5D12) Mouse Monoclonal Antibody","description":"Monoclonal Antibody for studying PPP2R5D\/PR61d. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, PPP2R5D (H5D12) Mouse Monoclonal Antibody (CST #5687) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPPP2R5D (H5D12) Mouse Monoclonal Antibody recognizes endogenous levels of total PPP2R5D\/PP2A, B'-δ\/B56-δ protein. This antibody cross-reacts with PPP2R4 and PPP2R2A protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human PPP2R5D protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nProtein Phosphatase 2A subunit isoform R5-δ (PPP2R5D) belongs to the R5\/B'\/B56 family of the regulatory subunit B of serine\/threonine phosphatase 2A (1). PPP2R5D (B-δ) is structurally related to the other components of subunit B, B-α. PPP2R5D lacks the WD-40 repeats that are important for protein-protein interaction (1-2). Structural differences may contribute to distinct down stream effects (3) and directing PP2A nuclear localization (4). Current evidence suggests that in contrast to B-α, PPP2R5D modulates the TGF-β\/Actividin\/Nodal signaling pathways by restricting the downstream activities of the type I TGF-β receptors, ALK4, and ALK5 (3)\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n2A5D; B56D; B56delta; MGC2134; MGC8949; MRD35; PP2A B subunit isoform B'-delta; PP2A B subunit isoform B56-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-delta; PP2A, B subunit, B' delta isoform; PP2A, B subunit, B56 delta isoform; PP2A, B subunit, PR61 delta isoform; PP2A, B subunit, R5 delta isoform; PPP2R5D; protein phosphatase 2 regulatory subunit B'delta; protein phosphatase 2, regulatory subunit B (B56), delta isoform; protein phosphatase 2, regulatory subunit B', delta; protein phosphatase 2, regulatory subunit B', delta isoform; Serine\/threonine protein phosphatase 2A, 56 kDa regulatory subunit, delta isoform; Serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 66, 69\nSource\/Isotype: Mouse IgG1","brand":"CST","offers":[{"title":"Default Title","offer_id":46800990666921,"sku":"5687T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-5687t","provider":"Iright","version":"1.0","type":"link"}