{"product_id":"cst-56936s","title":"CST,  56936S, TMEM175 (F5G5U) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TMEM175 mouse. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, TMEM175 (F5G5U) Rabbit Monoclonal Antibody (CST #56936) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTMEM175 (F5G5U) Rabbit Monoclonal Antibody recognizes endogenous levels of total TMEM175 protein.\nSpecies Reactivity: Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of mouse TMEM175 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTransmembrane protein 175 (TMEM175) is a potassium channel located in the membrane of late endosomes and lysosomes. TMEM175 has been shown to regulate lysosomal membrane potential, pH stability, and organelle fusion. In contrast, TMEM175 deficiency impairs lysosomal pH stability, lysosome-mediated autophagosomal clearance, and mitochondrial clearance in cells (1). Dysfunctional mitophagy resulting from TMEM175 loss-of-function mutations has been implicated in several human central nervous system (CNS) diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD) (2-4). Recently, it has been discovered that TMEM175 plays a role in apoptosis, as it is directly inhibited through binding of the anti-apoptotic regulator Bcl-2 (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n3010001K23Rik; AI504381; endosomal\/lysomomal potassium channel TMEM175; Endosomal\/lysosomal potassium channel TMEM175; Endosomal\/lysosomal proton channel TMEM175; mTMEM175; TM175; Tmem175; Transmembrane protein 175\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M R\nSENSITIVITY: Endogenous\nMW (kDa): 60\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800104259753,"sku":"56936S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-56936s","provider":"Iright","version":"1.0","type":"link"}