{"product_id":"cst-57058s","title":"CST,  57058S, IL-18 (E8P5O) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying IL18 mouse. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, IL-18 (E8P5O) Rabbit Monoclonal Antibody (CST #57058) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:5000 - 1:20000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 82990 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIL-18 (E8P5O) Rabbit Monoclonal Antibody recognizes endogenous levels of total mouse IL-18 protein. Non-specific staining was observed in mouse stomach crypts by immunohistochemistry.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant mouse IL-18 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nInterleukin-18 (IL-18), originally known as interferon-gamma inducing factor (IGIF), is part of the IL-superfamily of cytokines (1,2). This proinflammatory cytokine is synthesized as an inactive precursor which requires cleavage by Caspase-1 to become an active, mature molecule, which is secreted by monocytes and macrophages (3,4,6). It induces IFNγ production in T-helper-1 (Th1) cells and natural killer (NK) cells, and can regulate innate immunity via both Th1 and Th2 responses (4,5). Elevated IL-18 levels are associated with autoimmune disease, but may be balanced by binding to IL-18 binding protein (IL-18BP), which along with IL-18 neutralizing antibodies, are being examined in clinical trials (6,7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nIFN-gamma-inducing factor; Igif; IL 18; Il-; IL-1 gamma; IL-18; Il18; Interferon gamma-inducing factor; interferon-gamma-inducing factor; interleukin 18; Interleukin-1 gamma; Interleukin-18\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nMW (kDa): 17, 22\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800105767081,"sku":"57058S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-57058s","provider":"Iright","version":"1.0","type":"link"}