{"product_id":"cst-57221s","title":"CST,  57221S, TNFSF15 (D1C8W) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TNFSF15. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, TNFSF15 (D1C8W) Rabbit Monoclonal Antibody (CST #57221) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10mM sodium HEPES (pH 7.5), 150mM NaCl, 100 μg\/ml, 50% glycerol and less than 0.02% sodium azide. Store at -20ºC. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTNFSF15 (D1C8W) Rabbit Monoclonal Antibody recognizes endogenous levels of total human TNFS15 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu88 of human TNFSF15 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTNFSF15 (TL1A), a member of the TNF superfamily of proteins, is a splice variant of the TL1\/VEGI gene (1). Endothelial cells, monocytes, macrophages, and dendritic cells express TL1A, which is upregulated by proinflammatory cytokines, microorganisms, and AMPK activation (1-4). TL1A activates the NF-κB and JNK pathways through its receptor, DR3 (1,5). TL1A may function as a costimulatory signal for T cell activation, specifically regulating Th17 cell development and proliferation (1,2,6). Mouse models suggest a role for TL1A as a driver for the inflammation and pathogenesis associated with inflammatory bowel disease (7,8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nTL1; TL1A; TNF ligand-related molecule 1; TNF superfamily ligand TL1A; TNF superfamily member 15; TNF15; TNFSF15; TNLG1B; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand 1B; Tumor necrosis factor ligand superfamily member 15; Tumor necrosis factor ligand superfamily member 15, membrane form; Tumor necrosis factor ligand superfamily member 15, secreted form; tumor necrosis factor superfamily member 15; Vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor-192A; VEGI; VEGI192A\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 35\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800992960681,"sku":"57221S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-57221s","provider":"Iright","version":"1.0","type":"link"}