{"product_id":"cst-57299t","title":"CST,  57299T, R-Ras2 (F6T8H) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying RRas2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, R-Ras2 (F6T8H) Rabbit Monoclonal Antibody (CST #57299) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nR-Ras2 (F6T8H) Rabbit Monoclonal Antibody recognizes endogenous levels of total R-Ras2 protein. This antibody does not cross-react with either R-Ras1 or R-Ras3 proteins.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human R-Ras2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nR-Ras2 (TC21) belongs to the R-Ras subfamily of small GTPases, which includes R-Ras1 and R-Ras3 (M-Ras). Similar to the classical Ras proteins, R-Ras2 is palmitoylated and farnesylated at its carboxy terminus, which facilitates association with membranes and potent activation of the ERK\/MAPK and PI3K signaling cascades. Research studies have identified a role for R-Ras2 in the homeostasis of the adaptive immune system by demonstrating that loss of R-Ras2 expression impairs the proliferation and survival of lymphocytes in both the T cell and B cell compartments (1-3). R-Ras2 has also been implicated in human cancers. Indeed, overexpression of R-Ras2 has been observed in both lymphoid malignancies and solid tumor settings, concomitant with hyperactivation of signaling nodes that drive cell proliferation and survival (1,3-5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nNS12; RAS related 2; Ras-like protein TC21; Ras-related protein R-Ras2; related RAS viral (r-ras) oncogene homolog 2; RRAS2; TC21; Teratocarcinoma oncogene\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 25\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800993976489,"sku":"57299T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-57299t","provider":"Iright","version":"1.0","type":"link"}