{"product_id":"cst-57529s","title":"CST,  57529S, Human IL-11 Recombinant Protein","description":"Growth Factors and Cytokines for studying IL11 in the research area.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nHuman IL-11 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg\/ml which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles if storing reconstituted material at -20ºC to -80ºC.\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nRecombinant human IL-11 was expressed in and is supplied in a lyophilized form.\n\u003cb\u003eBackground\u003c\/b\u003e\nInterleukin-11 (IL-11) was initially cloned as a mediator of plasmacytoma cell proliferation and was later found to exhibit a wide variety of biological effects in neural cells as well as in the hematopoietic and immune systems (1). IL-11 belongs to the interleukin-6 (IL-6)-type subfamily of long-chain helical cytokines, including IL-6, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M, and cardiotrophin-1, which all share the glycoprotein gp130 as a signal transducing receptor component. IL-11 acts on cells expressing gp130 and the IL-11 receptor (IL-11R) α subunit. Both receptor subunits belong to the family of class I cytokine receptors. The complex of IL-11 and IL-11R triggers the activation of gp130 most likely by enforcing gp130 homodimerization (2). As a consequence of gp130 activation, several cytoplasmic signal transduction cascades are initiated from the Janus kinase (Jak)\/signal transducer and activator of transcription (Stat) pathway, which has attracted considerable attention. Initiation of the Jak\/Stat pathway in response to IL-11 requires Jak1 and leads predominantly to the activation of Stat3 (3,4).","brand":"CST","offers":[{"title":"Default Title","offer_id":46800715088041,"sku":"57529S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-57529s","provider":"Iright","version":"1.0","type":"link"}