{"product_id":"cst-57599s","title":"CST,  57599S, CXCL10 (F9N8I) Rabbit Monoclonal Antibody (Alexa Fluor® 647 Conjugate)","description":"Monoclonal Antibody for studying CXCL10. Validated for Immunohistochemistry (Paraffin). Highly specific and rigorously validated in-house, CXCL10 (F9N8I) Rabbit Monoclonal Antibody (Alexa Fluor\u003csup\u003e®\u003c\/sup\u003e 647 Conjugate) (CST #57599) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nImmunohistochemistry (Paraffin): 1:100 - 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg\/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCXCL10 (F9N8I) Rabbit Monoclonal Antibody (Alexa Fluor\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human CXCL10 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nC-X-C motif chemokine ligand 10 (CXCL10, IP-10) is a chemokine produced by several cell types and induced in response to pro-inflammatory cytokines, such as IFN-gamma and TNF-alpha (1,2). CXCL10 binds to the chemokine receptor CXCR3 and induces calcium flux and cell migration (3). The CXCR3 protein is normally expressed on activated CD4 T cells and NK cells, which can produce pro-inflammatory cytokines, including IFN-gamma and TNF-alpha (3,4). As a result, these molecules act in an amplification loop to promote immune responses in the contexts of both autoimmunity and a tumor immune response (5,6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n10 kDa interferon gamma-induced protein; C-X-C motif chemokine 10; C-X-C motif chemokine ligand 10; C7; chemokine (C-X-C motif) ligand 10; crg-2; CXCL10; CXCL10(1-73); CXL10; gamma IP10; Gamma-IP10; gIP-10; IFI10; INP10; interferon-inducible cytokine IP-10; IP-10; IP10; mob-1; protein 10 from interferon (gamma)-induced cell line; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member 10; Small-inducible cytokine B10\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801055580329,"sku":"57599S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-57599s","provider":"Iright","version":"1.0","type":"link"}