{"product_id":"cst-57946s","title":"CST,  57946S, OLR1\/LOX1 (E9C5A) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying OLR1. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, OLR1\/LOX1 (E9C5A) Rabbit Monoclonal Antibody (CST #57946) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:50 - 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 20752 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nOLR1\/LOX1 (E9C5A) Rabbit Monoclonal Antibody recognizes endogenous levels of total OLR1\/LOX1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val230 of human OLR1\/LOX1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nOxidatively modified low-density lipoprotein (Ox-LDL) causes endothelial cell dysfunction and activation and contributes to atherosclerosis. Oxidized low-density lipoprotein receptor 1 (OLR1), also known as lectin-like oxidized LDL receptor 1 (LOX1), was cloned and identified as a cell membrane receptor for Ox-LDL in vascular endothelial cells (1). In addition, research studies show that is one of the most overexpressed genes in human polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) that regulate immune responses in cancer. OLR1\/LOX1 is a specific marker of human PMN-MDSC (2). Furthermore, OLR1\/LOX1 was shown to be upregulated in esophageal cancer. OLR1\/LOX1 deficiency stimulates autophagic cell death, inhibiting esophageal cancer development (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC-type lectin domain family 8 member A; CLEC8A; hLOX-1; Lectin-like oxidized LDL receptor 1; Lectin-like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1; LOX-1; LOX1; LOXIN; OLR1; ox LDL receptor 1; Ox-LDL receptor 1; oxidized low density lipoprotein (lectin-like) receptor 1; oxidized low density lipoprotein receptor 1; Oxidized low-density lipoprotein receptor 1; Oxidized low-density lipoprotein receptor 1, soluble form; SCARE1; scavenger receptor class E, member 1; SLOX1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 35-42\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800998564009,"sku":"57946S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-57946s","provider":"Iright","version":"1.0","type":"link"}