{"product_id":"cst-57981s","title":"CST,  57981S, FBXO7 (D8L4E) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying FBXO7. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, FBXO7 (D8L4E) Rabbit Monoclonal Antibody (CST #57981) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nFBXO7 (D8L4E) Rabbit Monoclonal Antibody recognizes endogenous levels of total FBXO7 protein. This antibody detects two bands bands in human cerebellum, consistent with multiple FBXO7 isoforms generated by alternative splicing.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the N-terminus of human FBXO7 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nF-box only protein 7 (FBXO7) is the substrate recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. This complex mediates ubiquitination and degradation of targeted proteins. Several \" \" chromosomal loci have been associated with monogeneic forms of PD, including (1). The associated allele for is , which encodes the FBXO7 protein. Mutations in cause early-onset autosomal recessive PD, and alterations in FBXO7 normal function, e.g. the protein degradation process, may contribute to PD etiology (2, 3). Additionally, expression of specific FBXO7 isoforms generated by alternative splicing is linked with PD (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDKFZp686B08113; F-box only protein 7; F-box protein 7; FBX; FBX07; FBX7; FBXO7; PARK15; PKPS\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 65-72\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800998826153,"sku":"57981S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-57981s","provider":"Iright","version":"1.0","type":"link"}