{"product_id":"cst-58170s","title":"CST,  58170S, SARS-CoV-2 3C-Like Protease (E6O8L) Mouse Monoclonal Antibody","description":"Monoclonal Antibody for studying 3C-L proteinase SARS-CoV-2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, SARS-CoV-2 3C-Like Protease (E6O8L) Mouse Monoclonal Antibody (CST #58170) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSARS-CoV-2 3C-Like Protease (E6O8L) Mouse Monoclonal Antibody recognizes endogenous levels of total SARS-CoV-2 3C-like protease protein in infected cells.\nSpecies Reactivity: Virus\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of SARS-CoV-2 3C-like protease protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe cause of the COVID-19 pandemic is a novel and highly pathogenic coronavirus, termed SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). SARS-CoV-2 is a member of the Coronaviridae family of viruses (1). The genome of SARS-CoV-2 is relatively large and encodes up to 29 open reading frames (ORFs). These include ORF1a and ORF1b (further processed into 16 non-structural proteins), 9 accessory proteins, and 4 canonical structural proteins: spike (S), envelope (E), membrane (M), and nucleocapsid (N) (2). SARS-CoV-2 3C-like protease, also known as Main protease (Mpro), is a non-structural protein (Nsp5) that is derived from ORF1a and ORF1b (2). In a sequence of processing events involving another viral protease, Nsp3 (papain-like protease), 3C-like protease is cleaved from pp1a and pp1ab polyproteins. 3C-like protease is a cysteine-like protease that importantly is responsible for all subsequent polyprotein cleavage events that give rise to the components of the viral replicase complex (3). For this reason, inhibitors of 3C-like protease are of interest as antiviral targets (3,4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n3C-like proteinase; 3C-like proteinase-pp1a-pp1ab; 3CL-PRO; 3CLp; 3CLpro; M pro; Mpro; nsp5; SARS-CoV-2 3c-like proteinase\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: Vir\nSENSITIVITY: Endogenous\nMW (kDa): 38\nSource\/Isotype: Mouse IgG1 kappa","brand":"CST","offers":[{"title":"Default Title","offer_id":46800243982505,"sku":"58170S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-58170s","provider":"Iright","version":"1.0","type":"link"}