{"product_id":"cst-58173t","title":"CST,  58173T, SH2D1B\/EAT-2 (E2P5P) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying EAT-2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, SH2D1B\/EAT-2 (E2P5P) Rabbit Monoclonal Antibody (CST #58173) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSH2D1B\/EAT-2 (E2P5P) Rabbit Monoclonal Antibody recognizes endogenous levels of total SH2D1B\/EAT-2 protein. This antibody does not cross-react with SH2D1A\/SAP protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly92 of human SH2D1B\/EAT-2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSH2 domain-containing protein 1B\/EWS\/FLI1-activated transcript 2 (SH2D1B\/EAT-2) belongs to the SAP family of cytoplasmic signaling adaptor proteins. Structurally, SH2D1B\/EAT-2 is highlighted by a single SH2 domain and a short C-terminus containing multiple tyrosine residues whose phosphorylation regulate SH2D1B\/EAT-2 function (1,2). Research studies have demonstrated that SH2D1B\/EAT-2 is recruited to multiple SLAM family receptors in a phosphotyrosine-dependent manner and that phosphorylation of its C-terminal tyrosine residues is required for control of downstream signaling (3-5). SH2D1B\/EAT-2 expression has been detected in multiple hematopoietic cell lineages, including NK cells and macrophages (4,6). Indeed, in murine NK cells, tyrosine phosphorylation of SH2D1B\/EAT-2 mediates inhibitory signaling downstream of 2B4\/SLAMF4 to suppress effector functions (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nEAT-2; EAT2; EWS\/FLI1-activated transcript 2; SH2 domain containing 1B; SH2 domain-containing molecule EAT2; SH2 domain-containing protein 1B; SH21B; SH2D1B\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 15\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800999743657,"sku":"58173T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-58173t","provider":"Iright","version":"1.0","type":"link"}