{"product_id":"cst-58258t","title":"CST,  58258T, PSPH (E1D2X) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PSPH. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PSPH (E1D2X) Rabbit Monoclonal Antibody (CST #58258) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPSPH (E1D2X) Rabbit Monoclonal Antibody recognizes endogenous levels of total PSPH protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly141 of human PSPH protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSerine biosynthesis involves sequential reactions catalyzed by several metabolic enzymes, including phosphoserine phosphatase (PSPH). PSPH catalyzes the dephosphorylation of phospho-L-serine to L-serine, the last irreversible step in serine biosynthesis (1-3). Studies show that is overexpressed in melanoma samples, and this overexpression is essential for tumor growth and metastasis. knockdown in melanoma cells leads to increased 2-hydroxyglutarate (2-HG) levels. 2-HG suppresses melanoma cell growth (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nL-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase; Phosphoserine phosphatase; PSP; PSPase; PSPH; PSPHD; SERB\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 25\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801000333481,"sku":"58258T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-58258t","provider":"Iright","version":"1.0","type":"link"}