{"product_id":"cst-58269s","title":"CST,  58269S, Mouse IL-22 Recombinant Protein","description":"Growth Factors and Cytokines for studying IL22 mouse in the research area.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nMouse IL-22 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg\/ml which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles if storing reconstituted material at -20ºC to -80ºC.\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nRecombinant mouse IL-22 was expressed in and is supplied in a lyophilized form.\n\u003cb\u003eBackground\u003c\/b\u003e\nInterleukin-22 (IL-22), a member of the IL-10 family (1,2), is expressed by Th17 CD4 T cells, activated T cells, Th1 cells, and NK cells (3). Expression of IL-22 in combination with a select group of cytokines defines a subset of Th cells (4). IL-22 induces proinflammatory responses, drives production of antimicrobial peptides, and is involved in tissue repair and wound healing responses (1). The IL-22 receptor is a heterodimer of IL-22R1 and IL-10R2 (5). Expression of IL-22R is restricted to tissue-resident cells, particularly those of epithelial origin, whereas the IL-10R2 chain is expressed in many more cell types. IL-22 induces phosphorylation of Jak1 and Tyk2, leading to activation of Stat3 and, to a lesser extent, Stat1 and Stat5 (1). IL-22 responses can involve activation of the MEK-ERK-RSK, JNK-SAPK, and p38 pathways (1). Elevated levels of IL-22 have been associated with Crohn's disease and rheumatoid arthritis. IL-22 plays an essential role in host response to the pulmonary pathogen (6).","brand":"CST","offers":[{"title":"Default Title","offer_id":46800715120809,"sku":"58269S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-58269s","provider":"Iright","version":"1.0","type":"link"}