{"product_id":"cst-58363t","title":"CST,  58363T, Synaptojanin-2 (F7C1M) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SYNJ2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Synaptojanin-2 (F7C1M) Rabbit Monoclonal Antibody (CST #58363) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSynaptojanin-2 (F7C1M) Rabbit Monoclonal Antibody recognizes endogenous levels of total SYNJ2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human SYNJ2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSynaptojanin (SYNJ) is a phosphatidylinositol (PI) phosphatase located on the plasma membrane (1). SYNJ1 is a brain-enriched presynaptic phosphatase involved in synaptic vesicle recycling, clathrin-coated vesicle uncoating at synapse. While SYNJ1 is brain-specific, its paralog SYNJ2 is ubiquitously expressed. SYNJ2 is also abundantly expressed in the synapse and inhibits clathrin-mediated endocytosis (2). The main function of both SYNJ1 and SYNJ2 is to remove the five-position phosphates from PI (3,4,5)-trisphosphate (PIP ) and PI 4,5-bisphosphate (PIP ) (3). Genetic variations in are widely associated with human disease, such as reduced cognitive ability, Alzheimer's disease (AD), depression, Parkinson's disease (PD), medulloblastoma, prostate cancer, breast cancer, and lung cancer (4-10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\ninositol phosphate 5'-phosphatase 2; inositol phosphate 5'-phosphatase 2 (synaptojanin 2); inositol polyphosphate-5-phosphatase H; INPP5H; KIAA0348; MGC44422; phosphoinositide 5-phosphatase; Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2; Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 2; synaptojanin 2; Synaptojanin-2; SYNJ2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 200\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801001316521,"sku":"58363T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-58363t","provider":"Iright","version":"1.0","type":"link"}