{"product_id":"cst-58981t","title":"CST,  58981T, Optineurin (D2L8S) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying optineurin. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Optineurin (D2L8S) Rabbit Monoclonal Antibody (CST #58981) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nOptineurin (D2L8S) Rabbit Monoclonal Antibody recognizes endogenous levels of total optineurin protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu410 of human optineurin protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nOptineurin is a signaling protein involved in maintenance of the Golgi complex, membrane trafficking, NF-κB, and interferon signaling. Mutations in the gene encoding optineurin have been associated with human diseases including glaucoma, Paget disease of bone, and amyotrophic lateral sclerosis (ALS) (1-2). Optineurin is thought to contribute to these pathologies through regulation of inflammatory signaling, autophagy, and mitophagy (1, 3). The NF-κB-activating kinase\/TANK-binding kinase 1 (NAK\/TBK1) phosphorylates optineurin at serine 177, regulating optineurin's role in autophagy and mitophagy (4-6). The tumor suppressor HACE1 ubiquitylates optineurin, promoting the interaction of optineurin with the autophagy receptor p62\/SQSTM1 (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nALS12; E3-14.7K-interacting protein; FIP-2; FIP2; GLC1E; HIP-7; HIP7; Huntingtin interacting protein L; Huntingtin yeast partner L; Huntingtin-interacting protein 7; Huntingtin-interacting protein L; HYPL; NEMO-related protein; NRP; Optic neuropathy-inducing protein; Optineurin; OPTN; TFIIIA-IntP; Transcription factor IIIA-interacting protein; transcrption factor IIIA-interacting protein; tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 75\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801005674665,"sku":"58981T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-58981t","provider":"Iright","version":"1.0","type":"link"}