{"product_id":"cst-59027t","title":"CST,  59027T, LRIG1 (E1U2B) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying LRIG1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, LRIG1 (E1U2B) Rabbit Monoclonal Antibody (CST #59027) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nLRIG1 (E1U2B) Rabbit Monoclonal Antibody recognizes endogenous levels of total LRIG1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LRIG1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nLeucine-rich immunoglobulin repeats 1 (LRIG1) is a type I transmembrane protein containing 15 leucine-rich repeats and three immunoglobulin domains in the extracellular domain. Researchers characterize LRIG1 as a negative regulator of receptor tyrosine kinase signaling. In studies with ErbB family members and Met kinase, LRIG regulates signaling by increasing ubiquitination and lysosomal degradation of the receptors (1,2). Additional work indicates that LRIG1 plays a role in neurotropic signaling by negatively regulating Ret signaling (3,4). Expression profile studies demonstrate that LRIG1 is a marker in the quiescent population of stem cells in the intestine (5). Interestingly, the genetic ablation of one allele of LRIG1 in mice with an APC+\/- background results in development of highly dysplastic adenomas, indicating a role for LRIG1 in tumor suppression (1). Indeed, downregulation of LRIG1 is tentatively involved in tumor aggressiveness in several tumor types, including glioma (6), head and neck cancer (7), and cervical adenocarcinoma (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDKFZp586O1624; leucine rich repeats and immunoglobulin like domains 1; leucine-rich repeat protein LRIG1; leucine-rich repeats and immunoglobulin-like domains 1; Leucine-rich repeats and immunoglobulin-like domains protein 1; LIG-1; LIG1; LRIG1; ortholog of mouse integral membrane glycoprotein LIG-1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 140\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801006166185,"sku":"59027T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-59027t","provider":"Iright","version":"1.0","type":"link"}