{"product_id":"cst-5937s","title":"CST,  5937S, VMS1 (D10E6) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying VMS1 mouse. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, VMS1 (D10E6) Rabbit Monoclonal Antibody (CST #5937) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nVMS1 (D10E6) Rabbit Monoclonal Antibody detects endogenous levels of total VMS1 protein.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly332 of mouse VMS1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMitochondria are membrane-bound subcellular organelles critical to many functions in eukaryotic cells (1). Several mechanisms have been found to play a role in mitochondria quality control (2). A recent study identified mitochondria-associated protein degradation as one such mechanism (1,2). The study showed that VMS1 (VCP\/Cdc48-associated mitochondrial stress-responsive) interacts with VCP\/Cdc48 and Npl4, two components in the endoplasmic reticulum-associated protein degradation pathway, and mediates the degradation of damaged mitochondrial proteins under stress conditions (1). Defective VMS1 compromises mitochondrial functions and cell viability (1).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n1300008P06Rik; 2810025E10Rik; ankyrin repeat and zinc finger domain containing 1; ankyrin repeat and zinc finger domain containing protein; Ankyrin repeat and zinc finger domain-containing protein 1; ANKZ1; Ankzf1; D1Ertd161; D1Ertd161e; tRNA endonuclease ANKZF1; VMS1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nMW (kDa): 100\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800105963689,"sku":"5937S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-5937s","provider":"Iright","version":"1.0","type":"link"}