{"product_id":"cst-59460t","title":"CST,  59460T, RTN3 (F5X9D) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying RTN3. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, RTN3 (F5X9D) Rabbit Monoclonal Antibody (CST #59460) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nRTN3 (F5X9D) Rabbit Monoclonal Antibody recognizes endogenous levels of total RTN3 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human RTN3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nReticulon-3 (RTN3), a member of the reticulon protein family, plays a crucial role in maintaining the tubular shape and structural integrity of the endoplasmic reticulum (ER) network (1,2). The longest isoform of RTN3 (Rtn3L) carries six active LC3-interacting region domains, which are essential for LC3\/GABARAP binding, fragmentation of ER tubules, and its function as an ER-phagy receptor (3,4). Rtn3L is also recruited to ER-endosome membrane contact sites by the endosomal protein Rab9a, where it promotes endosome maturation and cargo sorting (5). RTN3 is highly expressed in neuronal tissues and is a negative modulator of β-amyloid converting enzyme 1 (BACE1), the enzyme that cleaves amyloid precursor protein (APP) to release β-amyloid peptides (6). Therefore, altered expression of RTN3 may modulate amyloid plaque formation, a hallmark of Alzheimer's disease (7,8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nASY interacting protein; ASYIP; HAP; homolog of ASY protein; isoforme III; isoforme VI; Neuroendocrine-specific protein-like 2; Neuroendocrine-specific protein-like II; NSP-like protein 2; NSP-like protein II; NSPL2; NSPLII; reticulon 3; Reticulon-3; RTN3; RTN3-A1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 25\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801009639593,"sku":"59460T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-59460t","provider":"Iright","version":"1.0","type":"link"}