{"product_id":"cst-59568s","title":"CST,  59568S, MARCKSL1 (D4I9P) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MLP. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MARCKSL1 (D4I9P) Rabbit Monoclonal Antibody (CST #59568) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMARCKSL1 (D4I9P) Rabbit Monoclonal Antibody recognizes endogenous levels of total MARCKSL1 protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro186 of human MARCKSL1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMyristoylated Alanine-Rich C-Kinase Substrate (MARCKS\/ MARCKS-like protein 1\/ MacMARCKS\/ MLP\/ MRP) is a widely expressed membrane-bound PKC substrate involved in multiple cellular functions (1). MARCKSL1 is a MARCKS homolog that also serves as a substrate for PKC, and regulates cytoskeletal dynamics, migration, adhesion, and proliferation. In response to phosphorylation by JNK, MARCKSL1 regulates migration and actin dynamics in neuronal and prostate cancer cells (2). In the developing retina, MARCKSL1 regulates cell proliferation, and its expression decreases as retinal development progresses (3). Researchers have shown that MARCKSL1 may serve as a prognostic marker in lymph node-negative breast cancer (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nF52; Mac-MARCKS; MacMARCKS; Macrophage myristoylated alanine-rich C kinase substrate; MARCKS like 1; MARCKS-like 1; MARCKS-like protein 1; MARCKS-related protein; MARCKSL1; MLP; MLP1; MRP\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 40\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801010065577,"sku":"59568S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-59568s","provider":"Iright","version":"1.0","type":"link"}