{"product_id":"cst-59840t","title":"CST,  59840T, Ron (E8M4A) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Ron. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Ron (E8M4A) Rabbit Monoclonal Antibody (CST #59840) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nRon (E8M4A) Rabbit Monoclonal Antibody recognizes endogenous levels of total Ron protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the cytoplasmic fragment of human Ron protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nRon is a member of the Met proto-oncogene family of receptor tyrosine kinases, which also includes Stk, c-Met, and c-Sea. The functional Ron is a heterodimer composed of a 40 kDa α chain and a 150 kDa β chain. Ron is initially synthesized in the cells as a single-chain, pro-Ron precursor that is cleaved into the two active chains. The α chain is completely extracellular, whereas the β chain traverses the cell membrane and contains the intracellular tyrosine kinase and regulatory elements (1,2). Ron mediates multiple signaling cascades that involve cell motility, adhesion, proliferation, and apoptosis. The signaling pathways activated downstream of Ron include the ras\/mitogen-activated protein kinase (MAPK), phosphatidyl inositol-3 kinase (PI3K)\/Akt, and focal adhesion kinase (FAK) pathways. Ron activation can also significantly increase c-Src activity, a signaling intermediate involved in cell cycle progression, motility, angiogenesis, and survival (3,4). The function of Ron has been shown to be important for embryological development as well as implicated in the progression and metastasis of tumors (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nc-met-related tyrosine kinase; CD136; CDw136; macrophage stimulating 1 receptor; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); Macrophage-stimulating protein receptor; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain; MSP receptor; MST1R; NPCA3; p185-Ron; Protein-tyrosine kinase 8; PTK8; PTK8 protein tyrosine kinase 8; RON; S13 avian erythroblastosis oncogene homolog; S13 erythroblastosis oncogene homolog; SEA; soluble RON variant 1; soluble RON variant 2; soluble RON variant 3; soluble RON variant 4\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 145, 150\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801011933353,"sku":"59840T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-59840t","provider":"Iright","version":"1.0","type":"link"}