{"product_id":"cst-60406t","title":"CST,  60406T, MGEA5\/OGA (E9C5U) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying OGA. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MGEA5\/OGA (E9C5U) Rabbit Monoclonal Antibody (CST #60406) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMGEA5\/OGA (E9C5U) Rabbit Monoclonal Antibody recognizes endogenous levels of total MGEA5\/OGA protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys545 of human MGEA5\/OGA protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nO-GlcNAcylation is a post-translational modification where β-D-N-acetylglucosamine (GlcNAc) is covalently linked to cytoplasmic and nuclear proteins at serine or threonine residues (1,2). This modification is important in many cellular processes, including metabolism, cell growth and morphogenesis, apoptosis, and transcription (2,3). The reversible protein modification by O-GlcNAc, which has been suggested to be a nutrient and stress sensor, is catalyzed by two highly conserved enzymes, O-GlcNAc transferase (OGT) and human meningioma-expressed antigen 5 (MGEA5)\/O-GlcNAcase (OGA) (4). Research studies have implicated O-GlcNAcylation in cancer (1). This modification has also been proposed to have protective effects against the production and aggregation of toxic protein species associated with neurodegenerative diseases, including amyloid β (Aβ) and tau (Alzheimer's disease), and α-synuclein (Parkinson's disease) (5-7). Â\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBeta-hexosaminidase; Beta-N-acetylglucosaminidase; Beta-N-acetylhexosaminidase; Bifunctional protein NCOAT; FLJ11229; FLJ23355; HAT; HEXC; Hexosaminidase C; Histone acetyltransferase; hyaluronidase in meningioma; KIAA0679; MEA5; meningioma expressed antigen 5 (hyaluronidase); Meningioma-expressed antigen 5; MGEA5; N-acetyl-beta-D-glucosaminidase; N-acetyl-beta-glucosaminidase; NCOAT; Nuclear cytoplasmic O-GlcNAcase and acetyltransferase; O-GlcNAcase; OGA; Protein O-GlcNAcase\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 138\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801014816937,"sku":"60406T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-60406t","provider":"Iright","version":"1.0","type":"link"}