{"product_id":"cst-60432t","title":"CST,  60432T, Fc-gamma RIIA (E3K8U) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying FcGR2A. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Fc-gamma RIIA (E3K8U) Rabbit Monoclonal Antibody (CST #60432) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nFc-gamma RIIA (E3K8U) Rabbit Monoclonal Antibody recognizes endogenous levels of total FcγRIIA protein. This antibody does not cross-react with FcγRIIB protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro170 of human FcγRIIA protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nFcγRIIA (CD32A) is a low affinity, IgG Fc-binding receptor belonging to the immunoglobulin receptor superfamily (1-3). In humans, it is expressed on myeloid cells, dendritic cells, and platelets (2-4). FcγRIIA is an activating-type Fc receptor, and signals through an immunoreceptor tyrosine-based activation motif (ITAM) present on its own IgG binding chain (2-4). ITAM signaling is essential for FcγRIIA-dependent phagocytosis and the induction of cytokine secretion (3). In addition to binding to IgG, FcγRI and FcγRII also bind to pentraxin proteins of the innate immune system (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCD32; CD32A; CDw32; Fc fragment of IgG receptor IIa; Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc gamma receptor RIIa3; Fc-gamma RII-a; Fc-gamma-RIIa; FCG2; FCG2A; FcGR; FCGR2; FCGR2A; FCGR2A1; FcRII-a; IGFR2; IgG Fc receptor II-a; Immunoglobulin G Fc receptor II; Low affinity immunoglobulin gamma Fc region receptor II-a; MGC23887; MGC30032\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 40-50\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801015111849,"sku":"60432T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-60432t","provider":"Iright","version":"1.0","type":"link"}