{"product_id":"cst-60758t","title":"CST,  60758T, NAF-1\/CISD2 (D4X4E) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CISD2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, NAF-1\/CISD2 (D4X4E) Rabbit Monoclonal Antibody (CST #60758) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nNAF-1\/CISD2 (D4X4E) Rabbit Monoclonal Antibody recognizes endogenous levels of total NAF-1\/CISD2 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu70 of human NAF-1\/CISD2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nNutrient-deprivation autophagy factor-1 (NAF-1) (also known as CISD2, CDGSH iron-sulfur domain-containing protein 2) is a member of NEET family of 2Fe-2S proteins, characterized by a unique CDGSH sequence at their Fe-S-cluster-binding domain (1). NAF-1\/CISD2 is a multifunctional protein. In addition to its role in iron and ROS homeostasis, it has been shown to play a role in autophagy, neurodegenerative diseases, and aging (1-6). Enhanced expression of NAF-1\/CISD2 is associated with many types of cancer. Silencing of NAF-1\/CISD2 expression in cancer cells significantly inhibited proliferation and tumorigenicity; while overexpression of NAF-1\/CISD2 significantly enhanced proliferation (2,7,8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCDGSH iron sulfur domain 2; CDGSH iron sulfur domain-containing protein 2; CDGSH iron-sulfur domain-containing protein 2; CDGSH2; CISD2; Endoplasmic reticulum intermembrane small protein; ERIS; Miner1; mitoNEET related 1; MitoNEET-related 1 protein; NAF-1; Nutrient-deprivation autophagy factor-1; WFS2; ZCD2; zinc finger, CDGSH-type domain 2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 15\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801016553641,"sku":"60758T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-60758t","provider":"Iright","version":"1.0","type":"link"}