{"product_id":"cst-60760s","title":"CST,  60760S, B7-H6 (E9Q7L) Rabbit Monoclonal Antibody (PE Conjugate)","description":"Monoclonal Antibody for studying B7-H6. Validated for Flow Cytometry (Live). Highly specific and rigorously validated in-house, B7-H6 (E9Q7L) Rabbit Monoclonal Antibody (PE Conjugate) (CST #60760) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFlow Cytometry (Live): 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg\/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Flow Cytometry (Live)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nB7-H6 (E9Q7L) Rabbit Monoclonal Antibody (PE Conjugate) recognizes endogenous levels of total B7-H6 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro185 of human B7-H6 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nB7-H6 (NCR3LG1) is a member of the B7 family of proteins that provide costimulatory signals for regulating T cell responses (1-3). B7-H6 is a ligand for the natural killer (NK)-cell-activating receptor NKp30, which triggers anti-tumor NK cell cytotoxicity and cytokine secretion (1). Both forms of B7-H6, cell surface B7-H6 and soluble B7-H6 (sB7-H6), are detected in primary tumors and the tumor microenvironment, but rarely in normal tissues (1-5). Cell surface B7-H6 associates with cell damage, and triggers innate immunity when it binds to NKp30 on NK cells (3,5). Soluble B7-H6 can decrease NKp30 expression on NK cells and induce NK cell dysfunction (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nB7 homolog 6; B7-H6; B7H6; DKFZp686I21167; DKFZp686O24166; hypothetical protein DKFZp686O24166; Natural cytotoxicity triggering receptor 3 ligand 1; natural killer cell cytotoxicity receptor 3 ligand 1; NCR3LG1; NR3L1; Putative Ig-like domain-containing protein DKFZp686O24166\/DKFZp686I21167; YK047\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801066098857,"sku":"60760S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-60760s","provider":"Iright","version":"1.0","type":"link"}