{"product_id":"cst-61248s","title":"CST,  61248S, Phospho-Androgen Receptor (Ser310) (E7L2S) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Androgen Receptor (Ser310) phosphate. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Phospho-Androgen Receptor (Ser310) (E7L2S) Rabbit Monoclonal Antibody (CST #61248) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPhospho-Androgen Receptor (Ser310) (E7L2S) Rabbit Monoclonal Antibody recognizes endogenous levels of androgen receptor protein only when phosphorylated at Ser310.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser310 of human androgen receptor protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nAndrogen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding (1). This promotes nuclear localization and binding of AR to androgen response elements in androgen target genes. Research studies have shown that AR plays a crucial role in several stages of male development and the progression of prostate cancer (2,3). Ser310 is phosphorylated by CDK1 during mitosis, which regulates its activity and localization (4). High levels of Ser310 phosphorylation is correlated with longer survival in castration resistant prostate cancer (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAIS; ANDR; Androgen receptor; AR; AR8; DHTR; Dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; TFM\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 110\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801019895977,"sku":"61248S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-61248s","provider":"Iright","version":"1.0","type":"link"}