{"product_id":"cst-61401s","title":"CST,  61401S, Poly(I:C) Sodium Salt","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nPoly(I:C) Sodium Salt is supplied as a lyophilized powder. To prevent denaturation, reconstitute in water containing physiological salt concentrations. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nPoly(I:C) Sodium Salt, also known as polyinosinic-polycytidylic acid sodium salt, is a synthetic analog to double-stranded RNA (dsRNA) and potent activator of Toll-like receptor 3 (TLR3). The Toll-like receptor (TLR) family plays an important role in the innate immune response (1). TLR3 functions as a receptor for dsRNA typically associated with viral infection (2). Binding of dsRNA, or the analog Poly(I:C), to TLR3 triggers activation of transcription factors NF-κB and IRF3 through the adaptor protein TICAM-1\/TRIF (3,4). Studies have shown that combination treatment with Poly(I:C) can increase vaccine immunogenicity against viral and cancerous diseases (5,6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\ndsRNA; pIpC; Poly; Poly(I:C); Poly(IC); polyinosinic-polycytidylic; RNA; TLR; TLR3; toll-like receptor","brand":"CST","offers":[{"title":"Default Title","offer_id":46800696836265,"sku":"61401S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-61401s","provider":"Iright","version":"1.0","type":"link"}