{"product_id":"cst-61964t","title":"CST,  61964T, COL14A1 (E5W8S) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying COL14A1. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, COL14A1 (E5W8S) Rabbit Monoclonal Antibody (CST #61964) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:50 - 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 58865 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCOL14A1 (E5W8S) Rabbit Monoclonal Antibody recognizes endogenous levels of total COL14A1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human COL14A1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCOL14A1 (Collagen Type XIV, Undulin) is an interstitial collagen that belongs to the fibril-associated collagens with interrupted triple helices (FACIT) family (1). COL14A1 contributes to the assembly and remodeling of the interstitial extracellular matrix, in part by promoting the formation of inter-molecular bridges between collagen molecules (2-4). Changes in COL14A1 expression have been identified as a potential biomarker in a variety of fibrotic diseases, including idiopathic pulmonary fibrosis (5,6) and fibrotic kidney diseases (7). A study of tumor stroma-associated biomarkers furthermore revealed that was one of a group of genes whose expression correlated negatively with clinical stage of breast cancer patient samples (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCOEA1; COL14A1; Collagen alpha-1(XIV) chain; collagen type XIV alpha 1 chain; collagen, type XIV, alpha 1; UND; Undulin; undulin (fibronectin-tenascin-related)\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 220\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801025695913,"sku":"61964T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-61964t","provider":"Iright","version":"1.0","type":"link"}