{"product_id":"cst-62043t","title":"CST,  62043T, TRBP2 (D7C8K) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TRBP2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, TRBP2 (D7C8K) Rabbit Monoclonal Antibody (CST #62043) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTRBP2 (D7C8K) Rabbit Monoclonal Antibody recognizes endogenous levels of total TRBP2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro119 of human TRBP2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTrans-activation response (TAR) RNA binding protein (TRBP2) was initially discovered as a double stranded RNA binding protein (dsRBP) that bound TAR RNA sequences of the HIV-1 virus (1, 2). TRBP2 can bind to and inhibit the phosphorylation of protein kinase PKR, which leads to increased activation of the HIV-1 long terminal repeat (3,4). Along with PACT, TRBP2 is one of the dsRBPs in the RNA-induced silencing complex (RISC), where it plays a critical role in recruiting Ago2 to the miRNA bound by Dicer. (5-8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nLOQS; RISC-loading complex subunit TARBP2; TAR (HIV-1) RNA binding protein 2; TAR (HIV) RNA binding protein 2; TAR (HIV) RNA-binding protein 2; TAR (HIV) RNA-binding protein TRBP1; TAR RNA binding protein 2; TAR RNA-binding protein 2; TARBP2; TARBP2 subunit of RISC loading complex; TARBP2, RISC loading complex RNA binding subunit; trans-activation responsive RNA-binding protein; Trans-activation-responsive RNA-binding protein; TRBP; TRBP1; TRBP2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 44\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801026318505,"sku":"62043T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-62043t","provider":"Iright","version":"1.0","type":"link"}