{"product_id":"cst-62101s","title":"CST,  62101S, COX1\/MT-CO1 Antibody","description":"Polyclonal Antibody for studying COX1\/MT-CO1. Validated for Western Blotting. Highly specific and rigorously validated in-house, COX1\/MT-CO1 Antibody (CST #62101) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCOX1\/MT-CO1 Antibody recognizes endogenous levels of total COX1\/MT-CO1 protein. This antibody does not cross-react with COX2\/MT-CO2 protein or COX3\/MT-CO3 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human COX1\/MT-CO1 protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe mitochondrial electron transport chain comprises multiple protein complexes including cytochrome c oxidase. Cytochrome c oxidase catalyzes the reduction of oxygen to water. This process is coupled with pumping protons from the mitochondrial matrix into mitochondrial intermembrane space, contributing to the proton gradient used for ATP synthesis (1). Cytochrome c oxidase consists of 3 mitochondrial DNA-encoded subunits (COX1\/MT-CO1, COX2\/MT-CO2, and COX3\/MT-CO3) and multiple nuclear DNA-encoded subunits (2). Research studies show that the mRNAs of the mitochondrially encoded oxidative phosphorylation subunits, including COX1\/MT-CO1, decline significantly during aging (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCOI; COX1; COXI; cytochrome C oxidase; Cytochrome c oxidase polypeptide I; Cytochrome c oxidase subunit 1; cytochrome c oxidase subunit I; mitochondrially encoded cytochrome c oxidase I; MT-CO1; MT-COI; MTCO1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 32\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46801026875561,"sku":"62101S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-62101s","provider":"Iright","version":"1.0","type":"link"}