{"product_id":"cst-62114s","title":"CST,  62114S, CAPZA1 (E3U1G) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CAPZA1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, CAPZA1 (E3U1G) Rabbit Monoclonal Antibody (CST #62114) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCAPZA1 (E3U1G) Rabbit Monoclonal Antibody recognizes endogenous levels of total CAPZA1 protein. This antibody does not cross-react with CAPZA2 protein. Based on the sequence of the peptide antigen, this antibody is not expected to cross-react with CAPZA3 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg86 of human CAPZA1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe F-actin-capping protein, a ubiquitously expressed heterodimer composed of structurally similar α and β subunits, regulates cytoskeletal organization and function by binding to the actin filament barbed ends and maintaining the cellular pool of monomeric actin (1). F-actin-capping protein subunit α-1 (CAPZA1) overexpression is linked to more favorable prognosis in gastric cancer (2). In hepatocellular carcinoma, CAPZA1 inhibits epithelial-mesenchymal transition (EMT), migration, and invasion (3,4). Â\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCap Z; CAPPA1; capping actin protein of muscle Z-line alpha subunit 1; capping actin protein of muscle Z-line subunit alpha 1; capping protein (actin filament) muscle Z-line, alpha 1; CAPZ; CapZ alpha-1; CAPZA1; CAZ1; CAZA1; F-actin-capping protein subunit alpha-1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 33\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801027170473,"sku":"62114S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-62114s","provider":"Iright","version":"1.0","type":"link"}