{"product_id":"cst-62328s","title":"CST,  62328S, CSDE1 Antibody","description":"Polyclonal Antibody for studying CSDE1. Validated for Western Blotting. Highly specific and rigorously validated in-house, CSDE1 Antibody (CST #62328) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCSDE1 Antibody recognizes endogenous levels of total CSDE1 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CSDE1 protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nOriginally described as the product of an active transcription unit located upstream of the  gene (1), CSDE1 (cold shock domain-containing protein E1) is a highly conserved RNA-binding protein containing five cold-shock domains (2,3). CSDE1 is mostly localized in the cytoplasm where it interacts with distinct protein complexes involved in the post-transcriptional regulation of numerous mRNAs in a dynamic and complex manner (4). CSDE1 plays a role in maintaining the undifferentiated state of human embryonic stem cells (hESCs), and its loss results in accelerated neural differentiation and neurogenesis, partially via post-transcriptional regulation of fatty acid binding protein 7 ( ) and vimentin ( ) mRNAs (5). In human melanoma, increased CSDE1 protein expression has been shown to modulate the levels of pro-oncogenic factors such as vimentin or RAC1 and tumor suppressors such as PTEN, thus promoting tumor invasion and metastasis (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\ncold shock domain containing E1; cold shock domain containing E1, RNA binding; cold shock domain containing E1, RNA-binding; Cold shock domain-containing protein E1; CSDE1; D1S155E; DKFZp779B0247; DKFZp779J1455; FLJ26882; KIAA0885; N-ras upstream gene protein; NRAS-related; NRU; Protein UNR; RP5-1000E10.3; UNR; upstream of NRAS\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 89\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46801028776105,"sku":"62328S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-62328s","provider":"Iright","version":"1.0","type":"link"}