{"product_id":"cst-6248s","title":"CST,  6248S, MYH (D13D4) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MYH. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MYH (D13D4) Rabbit Monoclonal Antibody (CST #6248) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMYH (D13D4) Rabbit Monoclonal Antibody recognizes endogenous levels of total MYH protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MYH protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nBase excision repair (BER) proteins catalyze the removal of incorrect or damaged bases, including oxidized bases, from DNA. N-glycosylases specific to a given lesion remove the incorrect base as the first step in BER. MYH is the mammalian ortholog of MutY, a DNA glycosylase that catalyzes the removal of 8-oxoG:A mismatches (1). Several MYH isoforms have been detected in human cells localizing to either the nucleus or the mitochondria (2). MYH interacts with DNA repair proteins and localizes to DNA damage foci after oxidative damage (3). Research studies have shown that mutations in the corresponding MYH gene are associated with human gastric (4) and colorectal (5-7) cancers.\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nA\/G-specific adenine DNA glycosylase; Adenine DNA glycosylase; CYP2C; hMYH; MGC4416; mutY DNA glycosylase; MutY homolog; mutY homolog (E. coli); mutY-like protein; MUTYH; MYH\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 55\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801029333161,"sku":"6248S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-6248s","provider":"Iright","version":"1.0","type":"link"}