{"product_id":"cst-62518s","title":"CST,  62518S, TNFRSF13C\/BAFF-R (E3C1Q) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying BAFF-R. Validated for Western Blotting,Immunoprecipitation,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, TNFRSF13C\/BAFF-R (E3C1Q) Rabbit Monoclonal Antibody (CST #62518) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\nImmunohistochemistry (Paraffin): 1:100 - 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier-free (BSA and azide free) version of this product see product # 79406.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTNFRSF13C\/BAFF-R (E3C1Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total TNFRSF13C\/BAFF-R protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TNFRSF13C\/BAFF-R protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nB cell-activating factor (BAFF)-receptor (BAFF-R) is a type III transmembrane protein that is expressed almost exclusively on the surface of normal, mature B cells as well as malignant B cells from various forms of B cell lymphoproliferative disorders (1). Unlike BCMA and TACI, BAFF-R only binds BAFF and this interaction plays a fundamental role in driving B cell survival and proliferation by engaging canonical and non-canonical NF-κB signaling modules (2-4). Because its expression is largely restricted to the B cell lineage, BAFF-R is being investigated as an additional immunotherapeutic target for B cell malignancies (5,6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nB cell-activating factor receptor; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BAFFR; BLyS receptor 3; BR3; BROMIX; CD268; CVID4; MGC138235; prolixin; TNF receptor superfamily member 13C; TNFRSF13C; TR13C; Tumor necrosis factor receptor superfamily member 13C; tumor necrosis factor receptor superfamily, member 13C\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 38, 50\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801029497001,"sku":"62518S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-62518s","provider":"Iright","version":"1.0","type":"link"}