{"product_id":"cst-62567t","title":"CST,  62567T, Transgelin 2 (E3R3I) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TAGLN2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Transgelin 2 (E3R3I) Rabbit Monoclonal Antibody (CST #62567) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTransgelin 2 (E3R3I) Rabbit Monoclonal Antibody recognizes endogenous levels of total transgelin 2 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro148 of human transgelin 2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTransgelin 2 (TAGLN2) is an actin binding protein with roles in migration and invasion of cancer cells. High expression of transgelin-2 indicates poor prognosis in diabetes-associated pancreatic ductal adenocarcinoma (1). Transgelin 2 plays a role in Toll-like receptor (TLR)-stimulated phagocytosis by macrophages (2), and regulates T cell activation (3). The transgelin 2 gene, , was identified as one of 11 genes included in a gene signature predictive of CDK4 phosphorylation, and of sensitivity to the CDK4\/6 inhibitor palbociclib (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nepididymis secretory sperm binding protein; Epididymis tissue protein Li 7e; HA1756; KIAA0120; SM22-alpha homolog; TAGL2; TAGLN2; transgelin 2; Transgelin-2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 22\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801029890217,"sku":"62567T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-62567t","provider":"Iright","version":"1.0","type":"link"}