{"product_id":"cst-62577t","title":"CST,  62577T, OMP25\/SYNJ2BP (F5X5O) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SYNJ2BP. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, OMP25\/SYNJ2BP (F5X5O) Rabbit Monoclonal Antibody (CST #62577) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nOMP25\/SYNJ2BP (F5X5O) Rabbit Monoclonal Antibody recognizes endogenous levels of total OMP25\/SYNJ2BP protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a recombinant protein specific to the amino terminus of human OMP25\/SYNJ2BP protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSynaptojanin-2 binding protein (SYNJ2BP), also known as OMP25, is a mitochondrial outer membrane protein that acts as a signaling hub, regulating crucial processes in the brain, including neuron function and inter-organelle communication. A key function of SYNJ2BP is managing the contact between mitochondria and the endoplasmic reticulum (ER), known as mitochondrial-ER contact sites (MERCs) (1). Specifically in neurons, SYNJ2BP and Synaptojanin-2 (SYNJ2) form a tethering complex that latches PTEN induced putative kinase 1 (PINK1) mRNA onto the mitochondria. This specialized mechanism enables the local translation of PINK1 in distal parts of the cell, ensuring that distant mitochondria receive a steady supply of the protein required to activate mitophagy (2). By regulating the contact points between the ER and mitochondria in the liver, SYNJ2BP also plays a role in regulating hepatic lipid flux (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nactivin receptor interacting protein 5; ARIP2; FLJ11271; FLJ41973; Mitochondrial outer membrane protein 25; OMP25; SYJ2B; synaptojanin 2 binding protein; Synaptojanin-2-binding protein; SYNJ2BP\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 16\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801029562537,"sku":"62577T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-62577t","provider":"Iright","version":"1.0","type":"link"}