{"product_id":"cst-62759t","title":"CST,  62759T, SLAMF3\/CD229 (E5E8A) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CD229. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, SLAMF3\/CD229 (E5E8A) Rabbit Monoclonal Antibody (CST #62759) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSLAMF3\/CD229 (E5E8A) Rabbit Monoclonal Antibody recognizes endogenous levels of total SLAMF3\/CD229 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a recombinant protein specific to the intracellular domain of human SLAMF3\/CD229 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSignaling lymphocytic activation molecule family 3 (SLAMF3\/CD229) is a type-I transmembrane glycoprotein belonging to the SLAM family of immunoreceptors. Research studies have demonstrated that SLAMF3\/CD229 is a homophilic, self-ligating receptor and expression is largely restricted to the surface of T cells and B cells (1,2). The extracellular domain of SLAMF3\/CD229 contains a duplicated immunoglobulin (Ig)-like variable-type domain and a duplicated Ig-like C2-type domain, while the cytoplasmic domain is subject to alternative splicing and contains multiple potential tyrosine phosphorylation sites capable of recruiting signaling molecules such as EAT-2 and SAP (1,3,4). Research studies have shown that SLAMF3\/CD229 is also highly overexpressed by multiple myeloma plasma cells and drives intracellular signaling cascades that promote plasma cell proliferation and survival (5-7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCD229; Cell surface molecule Ly-9; cell-surface molecule Ly-9; hly9; LY9; Lymphocyte antigen 9; mLY9; Signaling lymphocytic activation molecule 3; SLAM family member 3; SLAMF3; T-lymphocyte surface antigen Ly-9\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 120, 100\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801030414505,"sku":"62759T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-62759t","provider":"Iright","version":"1.0","type":"link"}